Comfort Inn & Suites Santee   221 Britain Street, Santee, SC 29142 US Check In Check Out 14+ Nights   10+ Rooms Rooms 1 2 3 4 5 6 7 8 9 10+ Adults/Rm 1 2 3 4 5 Photos of Comfort Inn & Suites Santee Hotel Info • Video • Map • Rates & Availability   Select check-in date Select check-out date Learn more about Santee Hotels in our Santee Hotels Guide. Comfort Inn & Suites Santee, 221 Britain Street, Santee, South Carolina SC 29142

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